Estraval Depot Injection contains Estradiol Valerate (typically 10 mg/ml), an oil-based, long-acting synthetic form of human estrogen. When injected into the muscle, it slowly releases estradiol into the bloodstream to maintain steady hormone levels over 2 to 4 weeks. Key UsesHormone Replacement Therapy (HRT): Relieves menopausal symptoms such as hot flashes, night sweats, mood changes, and vaginal dryness. Osteoporosis Prevention: Helps maintain bone mineral density and reduce fracture risk in postmenopausal women with estrogen deficiency. Hypoestrogenism: Treats low estrogen caused by primary ovarian failure, hypogonadism, or surgical removal of the ovaries. Gender-Affirming Hormone Therapy (GAHT): Prescribed under specialist care as part of feminizing hormone regimens. Side EffectsCommon & Mild:Nausea, mild bloating, or stomach discomfort Breast tenderness or swelling Mild headaches or mood fluctuations Mild weight changes or fluid retention Injection site soreness Serious (Seek Immediate Medical Care):Blood Clots / DVT / Pulmonary Embolism: Unexplained leg pain/swelling, sudden shortness of breath, or chest pain. Cardiovascular & Stroke Events: Sudden weakness, confusion, severe headache, or vision changes. Liver Issues: Yellowing of the eyes/skin (jaundice), dark urine, or severe right-upper abdominal pain. Unexplained Bleeding or Lumps: Sudden abnormal vaginal bleeding or new breast lumps. Important Precautions & AdministrationAdministration: This is an intramuscular (IM) injection only and must be administered by a qualified healthcare professional. Never self-inject unless specifically trained by a medical practitioner. Contraindications: Avoid taking this medication if you have a history of active blood clots, estrogen-sensitive cancers (e.g., breast or uterine cancer), severe liver disease, or unexplained vaginal bleeding. Pregnancy & Breastfeeding: It is strictly contraindicated in pregnancy. Smoking Warning: Avoid smoking while using estrogen therapy, as it significantly increases the risk of blood clots, stroke, and heart attacks.
