Letroguard 2.5 Tablet (commonly spelled as Letroguard/Letroguard-2.5) contains Letrozole (2.5 mg). It belongs to a class of medications called non-steroidal aromatase inhibitors. It works by blocking the aromatase enzyme, which stops the conversion of androgens into estrogen and significantly lowers estrogen levels in the body.
Letrozole 2.5 mg tablets, AI generated
Letrozole 2.5 mg tablets. Source: Practo
Key Uses
Hormone Receptor-Positive Breast Cancer: Primary treatment for postmenopausal women with early or advanced hormone-sensitive breast cancer to slow down or stop cancer cell growth.
Ovulation Induction (Fertility Treatment): Frequently prescribed off-label by fertility specialists to stimulate egg release in women experiencing infertility due to Polycystic Ovary Syndrome (PCOS) or anovulation.
How to Take
Breast Cancer Treatment: Taken once daily, continuously, with or without food, as directed by an oncologist.
Fertility Treatment: Taken as a short course (typically for 5 consecutive days starting early in the menstrual cycle, such as Day 2 to Day 6) under strict gynecological guidance.
Side Effects
Common & Mild:
Hot flashes, night sweats, or flushing
Joint, bone, or muscle pain (arthralgia)
Fatigue, weakness, or dizziness
Mild nausea or headache
Weight gain or increased sweating
Serious Side Effects (Contact Doctor Immediately):
Decreased Bone Mineral Density: Long-term use can weaken bones, increasing the risk of osteoporosis and fractures.
Elevated Cholesterol: Can cause hypercholesterolemia (high lipid levels).
Cardiovascular Symptoms: Chest pain, shortness of breath, or swelling in legs/ankles.
Important Precautions
Pregnancy Warning: Strictly contraindicated during pregnancy as it can cause fetal harm. Effective contraception must be confirmed prior to treatment.
Bone Health Monitoring: Patients on long-term therapy usually require baseline and periodic DEXA scans to monitor bone density, alongside calcium and Vitamin D supplementation.
Dizziness: May cause fatigue or lightheadedness; take caution when driving or operating machinery.
